Integrated photonics modular arithmetic processor

Integrated photonics computing has emerged as a promising approach to overcome the limitations of electronic processors in the post-Moore era, capitalizing on the superiority of photonic systems. However, present integrated photonics computing systems face challenges in achieving high-precision calculations, consequently limiting their potential applications, and their heavy reliance on analog-to-digital (AD) and digital-to-analog (DA) conversion interfaces undermines their performance. Here we propose an innovative photonic computing architecture featuring scalable calculation precision and a novel photonic conversion interface. By leveraging Residue Number System (RNS) theory, the high-precision calculation is decomposed into multiple low-precision modular arithmetic operations executed through optical phase manipulation. Those operations directly interact with the digital system via our proposed optical digital-to-phase converter (ODPC) and phase-to-digital converter (OPDC). Through experimental demonstrations, we showcase a calculation precision of 9 bits and verify the feasibility of the ODPC/OPDC photonic interface. This approach paves the path towards liberating photonic computing from the constraints imposed by limited precision and AD/DA converters.Comment: 23 pages, 9 figure

An Optical Analog-to-Digital Converter with Enhanced ENOB Based on MMI-Based Phase-Shift Quantization

An optical analog-to-digital converter (OADC) scheme with enhanced bit resolution by using a multimode interference (MMI) coupler as optical quantization is proposed. The mathematical simulation model was established to verify the feasibility and to investigate the robustness of the scheme. Simulation results show that 20 quantization levels (corresponding to 4.32 of effective number of bits (ENOB)) are realized by using only 6 channels, which indicates that the scheme requires much fewer quantization channels or modulators to realize the same amount of ENOB. The scheme is robust and potential for integration

Wavelength tolerance of an all-optical multi-logic gate based on XPM in a HNLF

We investigate the wavelength-dependent performance of an all-optical multi-logic gate based on XPM. Simulation results show that this scheme is applicable over the whole C-band when the wavelength separation is between4nm and33nm?2011 National Sun Yat-Sen Univ

Systemic Immune-Inflammatory Index, Tumor-Infiltrating Lymphocytes, and Clinical Outcomes in Esophageal Squamous Cell Carcinoma Receiving Concurrent Chemoradiotherapy

Background. Systemic inflammation may be involved in the entire cancer process as a promoter and is associated with antitumor immunity. The systemic immune-inflammation index (SII) has been shown to be a promising prognostic factor. However, the relationship between SII and tumor-infiltrating lymphocytes (TIL) have not been established in esophageal cancer (EC) patients receiving concurrent chemoradiotherapy (CCRT). Methods. Retrospective analysis of 160 patients with EC was performed, peripheral blood cell counts were collected, and TIL concentration was assessed in H&E-stained sections. Correlations of SII and clinical outcomes with TIL were analyzed. Cox proportional hazard model and Kaplan–Meier method were used to perform survival outcomes. Results. Compared with high SII, low SII had longer overall survival (OS) (P=0.036, hazard ratio (HR) = 0.59) and progression-free survival (PFS) (P=0.041, HR = 0.60). Low TIL showed worse OS (P<0.001, HR = 2.42) and PFS (P<0.001, HR = 3.05). In addition, research have shown that the distribution of SII, platelet-to-lymphocyte ratio, and neutrophil-to-lymphocyte ratio were negatively associated with the TIL state, while lymphocyte-to-monocyte ratio presented a positive correlation. Combination analysis observed that SIIlow + TILhigh had the best prognosis of all combinations, with a median OS and PFS of 36 and 22 months, respectively. The worst prognosis was identified as SIIhigh + TILlow, with a median OS and PFS of only 8 and 4 months. Conclusion. SII and TIL as independent predictors of clinical outcomes in EC receiving CCRT. Furthermore, the predictive power of the two combinations is much higher than a single variable

Design and optimization of evanescently coupled waveguide photodiodes

We present the design and optimization of evanescently coupled waveguide photodiodes(EC-WPDs) based on the coupling modes theory and the beam propagation method. Efficient focalization of the optical power in the absorber is achieved by an appropriate choice of index matching layers of EC-WPDs. Numerical simulation shows that high-speed(40 GHz), high quantum efficiency(81%) and high linearity photodiodes can be achieved, and EC-WPDs are promising devices for future optical communication systems.?2011 Chinese Institute of Electronics

Mode-Selective Photonic Lanterns for Orbital Angular Momentum Mode Division Multiplexing

We analyze the mode evolution in mode-selective photonic lanterns with respect to taper lengths, affected by possible mode phase differences varying along the taper. As a result, we design a three-mode orbital angular momentum (OAM) mode-selective photonic lantern by optimizing the taper length with mode crosstalk below &#8722;24 dB, which employs only one single mode fiber port to selectively generate one OAM mode

Optimal Design of Segmented Planar Imaging System Based on Rotation and CLEAN Algorithm

We propose a parity-baseline segmented planar imaging method with more frequency components by changing different baseline selection to achieve better imaging in the rotational process. A theoretical model of the parity-baseline segmented planar imaging system with rotational operation is built to analyze the imaging effect. The simulation results show that the imaging quality of the parity-baseline segmented planar imaging system has an approximately 20% increase by rotation compared with the conventional system. In addition, the CLEAN algorithm in radio astronomy imaging is also applied to the parity-baseline segmented planar imaging system, and the image quality is further improved by 55%. Such a new imaging method holds great potential toward astronomical observation and detection

Effect of p53 on lung carcinoma cells irradiated by carbon ions or X-rays

The study is to investigate the feasibility and advantages of heavy ion beams on radiotherapy. The cellular cycle and apoptosis, cell reproductive death and p53 expression evaluated with flow cytometry, clonogenic survival assays and Western blot analysis were examined in lung carcinoma cells after exposure to 89.63 MeV/u carbon ion and 6 MV X-ray irradiations, respectively. The results showed that the number colonyforming assay of A549 was higher than that of H1299 cells in two radiation groups; A549 cellular cycle was arrested in G(2)/M in 12 It and the percentage of apoptosis ascended at each time point of carbon ion radiation with doses, the expression of p53 upregulated with doses exposed to X-ray or carbon ion. The cell number in G(2)/M of H1299 and apoptosis were increasing at all time points with doses in C-12(6+) ion irradiation group. The results suggested that the effects of carbon ions or X rays irradiation on lung carcinoma cells were different, C-12(6+) ion irradiation could have more effect on upregulating the expression of p53 than X-ray, and the upregulated expression of p53 might produce the cellular cycle G(2)/M arrested, apoptosis increasing; and p53 gene might affect the lung cancer cells radiosensitivity.National Natural Science Foundation of China 10675151 10835011 Key Scientific Technology Research Projects of Gansu Province 0702NKDA045 0801NKDA001 Lanzhou 07-2-0